منابع مشابه
Agonist-induced vascular tone.
The cellular mechanisms underlying the agonist-induced sustained contraction of the vascular smooth muscle are reviewed in the light of the use of Ca2+ and the change of Ca2+ sensitivity of the contractile apparatus. It is generally accepted that the main trigger for contraction of vascular smooth muscle is the elevation of intracellular Ca2+ concentration. However, the measurement of intracell...
متن کاملEffects of extracellular pH on agonist-induced vascular tone of the cat ophthalmociliary artery.
PURPOSE To test whether changes in extracellular pH (pHe) in an in vitro preparation of the cat ophthalmociliary artery affect passive tone and agonist responses and whether the endothelial cells are mediators of any pH-induced effect. This will determine the ability of the ophthalmociliary artery to influence retinal and choroidal blood flow in response to metabolic stimuli. METHODS The isom...
متن کاملCaMKIIT287 and T305 regulate history-dependent increases in α agonist–induced vascular tone
CaMKII is a calcium and calmodulin-activated kinase that has been shown to regulate learning and memory in the brain, and contractility in blood vessels. Following Ca activation, CaMKII autophosphorylates, gaining a calcium-independent autonomous activity that reflects a molecular memory of having previously come into contact with calcium. The present study addresses whether the molecular memor...
متن کاملp66Shc regulates renal vascular tone in hypertension-induced nephropathy.
Renal preglomerular arterioles regulate vascular tone to ensure a large pressure gradient over short distances, a function that is extremely important for maintaining renal microcirculation. Regulation of renal microvascular tone is impaired in salt-sensitive (SS) hypertension-induced nephropathy, but the molecular mechanisms contributing to this impairment remain elusive. Here, we assessed the...
متن کاملTaurine and vascular tone modulation
Taurine, an ubiquitary amino acid in the organism, has important physiological functions like bile salt formation, neuronal excitability regulation, immunomodulation, electrolytes homeostasis preservation, osmoregulation, membrane stabilisation, apoptosis inhibition and cell protection. This review article is focusing on the complex vasoactive influence of the sulphur-amino acid and on the poss...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1989
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.13.6.835